Elucidating the Roles of Fenton Reactants in Drug‐Treated Cells by Using a Selective Rhodamine‐Thiophenol Fluorogenic Sensor

While Fenton chemistry has long been known to play a role in inducing cellular stress, there recent renewed interest understanding its roles health and disease. Here we describe fluorogenic rhodamine-thiophenol probe, RTFt1, which applies both chelation recognition strategies sense the reactants, Fe(II) H2O2. RTFt1 undergoes 200-fold increase red fluorescence emission presence of After confirming suitability this new probe models, demonstrated utility sensing that accompanies ferroptosis cisplatin-induced cytotoxicity. We found levels reactants increased when cells were treated with cisplatin or co-treated tubastatin A. This points for cytotoxic effects these treatments. expect will be able provide deeper more broadly biological systems.